YAP inhibits ERα and ER(+) breast cancer growth by disrupting a TEAD-ERα signaling axis

Hippo signaling restricts tissue growth by inhibiting the transcriptional effector YAP. Here we uncover a role of Hippo signaling and a tumor suppressor function of YAP in estrogen receptor positive (ER(+)) breast cancer. We find that inhibition of Hippo/MST1/2 or activation of YAP blocks the ERα tr...

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Detalles Bibliográficos
Autores principales: Li, Xu, Zhuo, Shu, Zhuang, Ting, Cho, Yong Suk, Wu, Guojin, Liu, Yuchen, Mu, Kun, Zhang, Kai, Su, Peng, Yang, Yingzi, Zhang, Cheng Cheng, Zhu, Jian, Jiang, Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9163075/
https://www.ncbi.nlm.nih.gov/pubmed/35654829
http://dx.doi.org/10.1038/s41467-022-30831-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9163075/
https://www.ncbi.nlm.nih.gov/pubmed/35654829
http://dx.doi.org/10.1038/s41467-022-30831-5

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