Complex effects on Ca(V)2.1 channel gating caused by a CACNA1A variant associated with a severe neurodevelopmental disorder

P/Q-type Ca(2+) currents mediated by Ca(V)2.1 channels are essential for active neurotransmitter release at neuromuscular junctions and many central synapses. Mutations in CACNA1A, the gene encoding the principal Ca(V)2.1 α(1A) subunit, cause a broad spectrum of neurological disorders. Typically, ga...

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Detalles Bibliográficos
Autores principales: Grosso, Benjamin J., Kramer, Audra A., Tyagi, Sidharth, Bennett, Daniel F., Tifft, Cynthia J., D’Souza, Precilla, Wangler, Michael F., Macnamara, Ellen F., Meza, Ulises, Bannister, Roger A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9163077/
https://www.ncbi.nlm.nih.gov/pubmed/35655070
http://dx.doi.org/10.1038/s41598-022-12789-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9163077/
https://www.ncbi.nlm.nih.gov/pubmed/35655070
http://dx.doi.org/10.1038/s41598-022-12789-y

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