FABP5 deletion in nociceptors augments endocannabinoid signaling and suppresses TRPV1 sensitization and inflammatory pain

The endocannabinoid anandamide (AEA) produces antinociceptive effects by activating cannabinoid receptor 1 (CB1). However, AEA also serves as an agonist at transient receptor potential vanilloid receptor 1 (TRPV1) in nociceptive sensory neurons, which may exacerbate pain. This potential functional d...

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Detalles Bibliográficos
Autores principales: Bogdan, Diane M., Studholme, Keith, DiBua, Adriana, Gordon, Chris, Kanjiya, Martha P., Yu, Mei, Puopolo, Michelino, Kaczocha, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9163147/
https://www.ncbi.nlm.nih.gov/pubmed/35655086
http://dx.doi.org/10.1038/s41598-022-13284-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9163147/
https://www.ncbi.nlm.nih.gov/pubmed/35655086
http://dx.doi.org/10.1038/s41598-022-13284-0

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