Convergent evolution of a parasite-encoded complement control protein-scaffold to mimic binding of mammalian TGF-β to its receptors, TβRI and TβRII

The mouse intestinal helminth Heligmosomoides polygyrus modulates host immune responses by secreting a transforming growth factor (TGF)-β mimic (TGM), to expand the population of Foxp3(+) T(regs). TGM comprises five complement control protein (CCP)-like domains, designated D1-D5. Though lacking homo...

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Detalles Bibliográficos
Autores principales: Mukundan, Ananya, Byeon, Chang-Hyeock, Hinck, Cynthia S., Cunningham, Kyle, Campion, Tiffany, Smyth, Danielle J., Maizels, Rick M., Hinck, Andrew P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9163516/
https://www.ncbi.nlm.nih.gov/pubmed/35500648
http://dx.doi.org/10.1016/j.jbc.2022.101994

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9163516/
https://www.ncbi.nlm.nih.gov/pubmed/35500648
http://dx.doi.org/10.1016/j.jbc.2022.101994

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