Cargando…

Convergent evolution of a parasite-encoded complement control protein-scaffold to mimic binding of mammalian TGF-β to its receptors, TβRI and TβRII

The mouse intestinal helminth Heligmosomoides polygyrus modulates host immune responses by secreting a transforming growth factor (TGF)-β mimic (TGM), to expand the population of Foxp3(+) T(regs). TGM comprises five complement control protein (CCP)-like domains, designated D1-D5. Though lacking homo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mukundan, Ananya, Byeon, Chang-Hyeock, Hinck, Cynthia S., Cunningham, Kyle, Campion, Tiffany, Smyth, Danielle J., Maizels, Rick M., Hinck, Andrew P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9163516/ https://www.ncbi.nlm.nih.gov/pubmed/35500648 http://dx.doi.org/10.1016/j.jbc.2022.101994

Ejemplares similares

CD44 acts as a coreceptor for cell-specific enhancement of signaling and regulatory T cell induction by TGM1, a parasite TGF-β mimic
por: van Dinther, Maarten, et al.
Publicado: (2023)

Molecular characterization and expression of TGFβRI and TGFβRII and its association with litter size in Tibetan sheep
por: Zhang, Junxia, et al.
Publicado: (2023)

Suppression of airway allergic eosinophilia by Hp‐TGM, a helminth mimic of TGF‐β
por: Chauché, Caroline, et al.
Publicado: (2022)

A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells
por: Johnston, Chris J. C., et al.
Publicado: (2017)

Biological Activity Differences between TGF-β1 and TGF-β3 Correlate with Differences in the Rigidity and Arrangement of Their Component Monomers
por: Huang, Tao, et al.
Publicado: (2014)

Alternative splicing of TGF-betas and their high-affinity receptors TβRI, TβRII and TβRIII (betaglycan) reveal new variants in human prostatic cells
por: Konrad, Lutz, et al.
Publicado: (2007)

Crosstalk between the p38 and TGF-β signaling pathways through TβRI, TβRII and Smad3 expression in plancental choriocarcinoma JEG-3 cells
por: TAN, YUSI, et al.
Publicado: (2014)

Mutation of TGFβ-RII eliminates NSAID cancer chemoprevention
por: Martín-López, Juana, et al.
Publicado: (2017)

TGF-β in tolerance, development and regulation of immunity
por: Johnston, Chris J.C., et al.
Publicado: (2016)

The parasite cytokine mimic Hp‐TGM potently replicates the regulatory effects of TGF‐β on murine CD4(+) T cells
por: White, Madeleine P J, et al.
Publicado: (2021)

PAR1 Scaffolds TGFβRII to Downregulate TGF-β Signaling and Activate ESC Differentiation to Endothelial Cells
por: Gong, Haixia, et al.
Publicado: (2016)

An oncolytic virus–delivered TGFβ inhibitor overcomes the immunosuppressive tumor microenvironment
por: DePeaux, Kristin, et al.
Publicado: (2023)

TGF-β mimic proteins form an extended gene family in the murine parasite Heligmosomoides polygyrus
por: Smyth, Danielle J., et al.
Publicado: (2018)

Gene Silencing of TGFβRII Can Inhibit Glioblastoma Cell Growth
por: Aval, Farzane Ordoni, et al.
Publicado: (2018)

Induction of stable human FOXP3(+) Tregs by a parasite‐derived TGF‐β mimic
por: Cook, Laura, et al.
Publicado: (2021)

Hydroxysafflor Yellow A Suppresses MRC-5 Cell Activation Induced by TGF-β1 by Blocking TGF-β1 Binding to TβRII
por: Pan, Ruiyan, et al.
Publicado: (2017)

TGF-β triggers rapid fibrillogenesis via a novel TβRII-dependent fibronectin-trafficking mechanism
por: Varadaraj, Archana, et al.
Publicado: (2017)

The TGFβ type I receptor TGFβRI functions as an inhibitor of BMP signaling in cartilage
por: Wang, Weiguang, et al.
Publicado: (2019)

Oral delivery of a functional algal-expressed TGF-β mimic halts colitis in a murine DSS model
por: Smyth, Danielle J., et al.
Publicado: (2021)

The miR-130a-3p/TGF-βRII Axis Participates in Inhibiting the Differentiation of Fibroblasts Induced by TGF-β1
por: Liu, Yanhong, et al.
Publicado: (2021)

Protein kinase C βII and TGFβRII in ω-3 fatty acid–mediated inhibition of colon carcinogenesis
por: Murray, Nicole R., et al.
Publicado: (2002)

Clinical Implications of TβRII Expression in Breast Cancer
por: Gao, Ningning, et al.
Publicado: (2015)

Immunohistochemical Expression of TGF-Β1, SMAD4, SMAD7, TGFβRII and CD68-Positive TAM Densities in Papillary Thyroid Cancer
por: Ivanova, Koni, et al.
Publicado: (2018)

MicroRNA‐30c suppresses the pro‐fibrogenic effects of cardiac fibroblasts induced by TGF‐β1 and prevents atrial fibrosis by targeting TGFβRII
por: Xu, Juan, et al.
Publicado: (2018)

Down-regulation of transforming growth factor-β type II receptor (TGF-βRII) protein and mRNA expression in cervical cancer
por: Diaz-Chavez, Jose, et al.
Publicado: (2008)

Single Turnover Autophosphorylation Cycle of the PKA RIIβ Holoenzyme
por: Zhang, Ping, et al.
Publicado: (2015)

EPRS1 Controls the TGF-β Signaling Pathway via Interaction with TβRI in Hepatic Stellate Cell
por: Yoon, Ina, et al.
Publicado: (2023)

Dual targeting of TGF-β and PD-L1 via a bifunctional anti-PD-L1/TGF-βRII agent: status of preclinical and clinical advances
por: Lind, Hanne, et al.
Publicado: (2020)

Opposed Actions of PKA Isozymes (RI and RII) and PKC Isoforms (cPKCβI and nPKCε) in Neuromuscular Developmental Synapse Elimination
por: Garcia, Neus, et al.
Publicado: (2019)

TGF-β uses a novel mode of receptor activation to phosphorylate SMAD1/5 and induce epithelial-to-mesenchymal transition
por: Ramachandran, Anassuya, et al.
Publicado: (2018)

LncRNA LITATS1 suppresses TGF‐β‐induced EMT and cancer cell plasticity by potentiating TβRI degradation
por: Fan, Chuannan, et al.
Publicado: (2023)

A novel highly potent trivalent TGF-β receptor trap inhibits early-stage tumorigenesis and tumor cell invasion in murine Pten-deficient prostate glands
por: Qin, Tai, et al.
Publicado: (2016)

Protection from T cell-dependent colitis by the helminth-derived immunomodulatory mimic of transforming growth factor-β, Hp-TGM
por: Smyth, Danielle J, et al.
Publicado: (2023)

Attenuation of corneal myofibroblast development through nanoparticle-mediated soluble transforming growth factor-β type II receptor (sTGFβRII) gene transfer
por: Sharma, Ajay, et al.
Publicado: (2012)

Protein Kinase A in Human Retina: Differential Localization of Cβ, Cα, RIIα, and RIIβ in Photoreceptors Highlights Non-redundancy of Protein Kinase A Subunits
por: Roa, Jinae N., et al.
Publicado: (2021)

Short hairpin RNA silencing of TGF-βRII and FZD-7 synergistically suppresses proliferation and metastasis of hepatocellular carcinoma cells
por: CHEN, CONG, et al.
Publicado: (2016)

TGF-βRII regulates glucose metabolism in oral cancer-associated fibroblasts via promoting PKM2 nuclear translocation
por: Wu, Fanglong, et al.
Publicado: (2022)

TGFβ(+) small extracellular vesicles from head and neck squamous cell carcinoma cells reprogram macrophages towards a pro‐angiogenic phenotype
por: Ludwig, Nils, et al.
Publicado: (2022)

Correction: A novel highly potent trivalent TGF-β receptor trap inhibits early-stage tumorigenesis and tumor cell invasion in murine Pten-deficient prostate glands
por: Qin, Tai, et al.
Publicado: (2017)

Focal adhesion molecule Kindlin-1 mediates activation of TGF-β signaling by interacting with TGF-βRI, SARA and Smad3 in colorectal cancer cells
por: Kong, Jinfeng, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_92gus8keq5sj8t7dhtdtaqsa7j