Genetic Reduction of Glucose Metabolism Preserves Functional β-Cell Mass in K(ATP)-Induced Neonatal Diabetes

β-Cell failure and loss of β-cell mass are key events in diabetes progression. Although insulin hypersecretion in early stages has been implicated in β-cell exhaustion/failure, loss of β-cell mass still occurs in K(ATP) gain-of-function (GOF) mouse models of human neonatal diabetes in the absence of...

Descripción completa

Detalles Bibliográficos
Autores principales: Yan, Zihan, Fortunato, Manuela, Shyr, Zeenat A., Clark, Amy L., Fuess, Matt, Nichols, Colin G., Remedi, Maria S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2022
Materias:
Islet Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9163553/
https://www.ncbi.nlm.nih.gov/pubmed/35294000
http://dx.doi.org/10.2337/db21-0992

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9163553/
https://www.ncbi.nlm.nih.gov/pubmed/35294000
http://dx.doi.org/10.2337/db21-0992

Ejemplares similares