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Genetic Reduction of Glucose Metabolism Preserves Functional β-Cell Mass in K(ATP)-Induced Neonatal Diabetes

β-Cell failure and loss of β-cell mass are key events in diabetes progression. Although insulin hypersecretion in early stages has been implicated in β-cell exhaustion/failure, loss of β-cell mass still occurs in K(ATP) gain-of-function (GOF) mouse models of human neonatal diabetes in the absence of...

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Detalles Bibliográficos
Autores principales:	Yan, Zihan, Fortunato, Manuela, Shyr, Zeenat A., Clark, Amy L., Fuess, Matt, Nichols, Colin G., Remedi, Maria S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2022
Materias:	Islet Studies
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9163553/ https://www.ncbi.nlm.nih.gov/pubmed/35294000 http://dx.doi.org/10.2337/db21-0992

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