The central inflammasome adaptor protein ASC activates the inflammasome after transition from a soluble to an insoluble state

Apoptosis-associated speck-like protein containing a caspase recruitment domain (CARD) (ASC) is a 22 kDa protein that functions as the central adaptor for inflammasome assembly. ASC forms insoluble specks in monocytes undergoing pyroptosis, and the polymerization of ASC provides a template of CARDs...

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Detalles Bibliográficos
Autores principales: Prather, Evan R., Gavrilin, Mikhail A., Wewers, Mark D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9163591/
https://www.ncbi.nlm.nih.gov/pubmed/35568196
http://dx.doi.org/10.1016/j.jbc.2022.102024

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9163591/
https://www.ncbi.nlm.nih.gov/pubmed/35568196
http://dx.doi.org/10.1016/j.jbc.2022.102024

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