The dual fates of exogenous tau seeds: Lysosomal clearance versus cytoplasmic amplification

Tau assembly movement from the extracellular to intracellular space may underlie transcellular propagation of neurodegenerative tauopathies. This begins with tau binding to cell surface heparan sulfate proteoglycans, which triggers macropinocytosis. Pathological tau assemblies are proposed then to e...

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Detalles Bibliográficos
Autores principales: Kolay, Sourav, Vega, Anthony R., Dodd, Dana A., Perez, Valerie A., Kashmer, Omar M., White, Charles L., Diamond, Marc I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9163595/
https://www.ncbi.nlm.nih.gov/pubmed/35525272
http://dx.doi.org/10.1016/j.jbc.2022.102014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9163595/
https://www.ncbi.nlm.nih.gov/pubmed/35525272
http://dx.doi.org/10.1016/j.jbc.2022.102014

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