Cargando…

The dual fates of exogenous tau seeds: Lysosomal clearance versus cytoplasmic amplification

Tau assembly movement from the extracellular to intracellular space may underlie transcellular propagation of neurodegenerative tauopathies. This begins with tau binding to cell surface heparan sulfate proteoglycans, which triggers macropinocytosis. Pathological tau assemblies are proposed then to e...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kolay, Sourav, Vega, Anthony R., Dodd, Dana A., Perez, Valerie A., Kashmer, Omar M., White, Charles L., Diamond, Marc I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9163595/ https://www.ncbi.nlm.nih.gov/pubmed/35525272 http://dx.doi.org/10.1016/j.jbc.2022.102014

Ejemplares similares

Alzheimer's disease risk modifier genes do not affect tau aggregate uptake, seeding or maintenance in cell models
por: Kolay, Sourav, et al.
Publicado: (2020)

The Fate of Tau Aggregates Between Clearance and Transmission
por: Seitkazina, Assel, et al.
Publicado: (2022)

RNA induces unique tau strains and stabilizes Alzheimer’s disease seeds
por: Zwierzchowski-Zarate, Amy N., et al.
Publicado: (2022)

VCP increases or decreases tau seeding using specific cofactors
por: Batra, Sushobhna, et al.
Publicado: (2023)

Ultrasensitive tau biosensor cells detect no seeding in Alzheimer’s disease CSF
por: Hitt, Brian D., et al.
Publicado: (2021)

Aggregated Tau activates NLRP3–ASC inflammasome exacerbating exogenously seeded and non-exogenously seeded Tau pathology in vivo
por: Stancu, Ilie-Cosmin, et al.
Publicado: (2019)

PIKfyve activity is required for lysosomal trafficking of tau aggregates and tau seeding
por: Soares, Alberto Carpinteiro, et al.
Publicado: (2021)

Tau monomer encodes strains
por: Sharma, Apurwa M, et al.
Publicado: (2018)

Novel antibody against low‐n oligomers of tau protein promotes clearance of tau in cells via lysosomes
por: Chandupatla, Ram Reddy, et al.
Publicado: (2020)

Amplification of Tau Fibrils from Minute Quantities of Seeds
por: Meyer, Virginia, et al.
Publicado: (2014)

Tau seed amplification assay reveals relationship between seeding and pathological forms of tau in Alzheimer’s disease brain
por: Frey, Bryan, et al.
Publicado: (2023)

Optical pulse labeling studies reveal exogenous seeding slows α-synuclein clearance
por: Croft, Cara L., et al.
Publicado: (2022)

Seeding Activity-Based Detection Uncovers the Different Release Mechanisms of Seed-Competent Tau Versus Inert Tau via Lysosomal Exocytosis
por: Tanaka, Yuki, et al.
Publicado: (2019)

CYTOPLASMIC COMPONENTS IN HEPATIC CELL LYSOSOMES
por: Ashford, Thomas P., et al.
Publicado: (1962)

α-Linolenic acid induces clearance of Tau seeds via Actin-remodeling in Microglia
por: Desale, Smita Eknath, et al.
Publicado: (2021)

Tau local structure shields an amyloid-forming motif and controls aggregation propensity
por: Chen, Dailu, et al.
Publicado: (2019)

Antibody-mediated clearance of tau in primary mouse microglial cultures requires Fcγ-receptor binding and functional lysosomes
por: Andersson, Christian Rungsted, et al.
Publicado: (2019)

Fate and propagation of endogenously formed Tau aggregates in neuronal cells
por: Chastagner, Patricia, et al.
Publicado: (2020)

DnaJC7 specifically regulates tau seeding
por: Perez, Valerie A., et al.
Publicado: (2023)

DnaJC7 specifically regulates tau seeding
por: Perez, Valerie Ann, et al.
Publicado: (2023)

Early fate of exogenous promoters in E. coli
por: Yousuf, Malikmohamed, et al.
Publicado: (2020)

Tau seeding in cases of multiple sclerosis
por: LaCroix, Michael S., et al.
Publicado: (2022)

DnaJC7 binds natively folded structural elements in tau to inhibit amyloid formation
por: Hou, Zhiqiang, et al.
Publicado: (2021)

Transcriptional Activation of Lysosomal Exocytosis Promotes Cellular Clearance
por: Medina, Diego L., et al.
Publicado: (2011)

Tau fibrils induce nanoscale membrane damage and nucleate cytosolic tau at lysosomes
por: Rose, Kevin, et al.
Publicado: (2023)

Effects of exogenous proteins on cytoplasmic streaming in perfused Chara cells
Publicado: (1982)

Alphavirus RNA replicase is located on the cytoplasmic surface of endosomes and lysosomes
Publicado: (1988)

Golgi Vesiculation and Lysosome Dispersion in Cells Lacking Cytoplasmic Dynein
por: Harada, A., et al.
Publicado: (1998)

Different fates of phagocytosed particles after delivery into macrophage lysosomes
Publicado: (1996)

Tau seeding activity begins in the transentorhinal/entorhinal regions and anticipates phospho-tau pathology in Alzheimer’s disease and PART
por: Kaufman, Sarah K., et al.
Publicado: (2018)

Lysosomal Dysfunction Promotes Cleavage and Neurotoxicity of Tau In Vivo
por: Khurana, Vikram, et al.
Publicado: (2010)

Tau differentially regulates the transport of early endosomes and lysosomes
por: Balabanian, Linda, et al.
Publicado: (2022)

Tau accumulation in degradative organelles is associated to lysosomal stress
por: Piovesana, Ester, et al.
Publicado: (2023)

The Fate of the Chlorophyll Derivatives in Olives Preserved and/or Packaged in Presence of Exogenous Copper
por: Natella, Fausta, et al.
Publicado: (2023)

β-Arrestin2 arrests the clearance of tau in FTLD
por: Thathiah, Amantha
Publicado: (2020)

Acetylation of the KXGS motifs in tau is a critical determinant in modulation of tau aggregation and clearance
por: Cook, Casey, et al.
Publicado: (2014)

The entry of diphtheria toxin into the mammalian cell cytoplasm: evidence for lysosomal involvement
Publicado: (1980)

Two Distinct Pathways for Targeting Proteins from the Cytoplasm to the Vacuole/Lysosome
por: Baba, Misuzu, et al.
Publicado: (1997)

Changes in lysosome shape and distribution correlated with changes in cytoplasmic pH
Publicado: (1989)

TFEB regulates lysosomal exocytosis of tau and its loss of function exacerbates tau pathology and spreading
por: Xu, Yin, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_1sm9sad7l23c51jcb57l310cnb