Safety, Pharmacokinetics/Pharmacodynamics, and Absolute Bioavailability of Dexmedetomidine Hydrochloride Nasal Spray in Healthy Subjects: A Randomized, Parallel, Escalating Dose Study

Background: The present study evaluated the safety, pharmacokinetics/pharmacodynamics (PK/PD), and absolute bioavailability (Fabs) of Dex nasal spray in healthy adult subjects, which serves as a bridge for the subsequent study in children. Methods: Part 1: a double-blind, placebo-controlled, single...

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Detalles Bibliográficos
Autores principales: Kuang, Yun, Wang, Sai-Ying, Wang, Meng-Na, Yang, Guo-Ping, Guo, Can, Yang, Shuang, Zhang, Xing-Fei, Yang, Xiao-Yan, Pei, Qi, Zou, Chan, He, Yan-Hong, Zhou, Ying-Yong, Duan, Kai-Ming, Huang, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9163677/
https://www.ncbi.nlm.nih.gov/pubmed/35668951
http://dx.doi.org/10.3389/fphar.2022.871492

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9163677/
https://www.ncbi.nlm.nih.gov/pubmed/35668951
http://dx.doi.org/10.3389/fphar.2022.871492

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