Transmembrane serine protease 2 (TMPRSS2) proteolytically activates the epithelial sodium channel (ENaC) by cleaving the channel’s γ-subunit

The epithelial sodium channel (ENaC) is a heterotrimer consisting of α-, β-, and γ-subunits. Channel activation requires proteolytic release of inhibitory tracts from the extracellular domains of α-ENaC and γ-ENaC; however, the proteases involved in the removal of the γ-inhibitory tract remain uncle...

Descripción completa

Detalles Bibliográficos
Autores principales: Sure, Florian, Bertog, Marko, Afonso, Sara, Diakov, Alexei, Rinke, Ralf, Madej, M. Gregor, Wittmann, Sabine, Gramberg, Thomas, Korbmacher, Christoph, Ilyaskin, Alexandr V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9163703/
https://www.ncbi.nlm.nih.gov/pubmed/35504352
http://dx.doi.org/10.1016/j.jbc.2022.102004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9163703/
https://www.ncbi.nlm.nih.gov/pubmed/35504352
http://dx.doi.org/10.1016/j.jbc.2022.102004

Ejemplares similares