Multi-platform quantitation of alpha-synuclein human brain proteoforms suggests disease-specific biochemical profiles of synucleinopathies

Based on immunostainings and biochemical analyses, certain post-translationally modified alpha-synuclein (aSyn) variants, including C-terminally truncated (CTT) and Serine-129 phosphorylated (pSer129) aSyn, are proposed to be involved in the pathogenesis of synucleinopathies such as Parkinson’s dise...

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Detalles Bibliográficos
Autores principales: Moors, Tim E., Mona, Daniel, Luehe, Stefan, Duran-Pacheco, Gonzalo, Spycher, Liz, Mundigl, Olaf, Kaluza, Klaus, Huber, Sylwia, Hug, Melanie N., Kremer, Thomas, Ritter, Mirko, Dziadek, Sebastian, Dernick, Gregor, van de Berg, Wilma D. J., Britschgi, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9164351/
https://www.ncbi.nlm.nih.gov/pubmed/35659116
http://dx.doi.org/10.1186/s40478-022-01382-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9164351/
https://www.ncbi.nlm.nih.gov/pubmed/35659116
http://dx.doi.org/10.1186/s40478-022-01382-z

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