Evolutionary perspectives, heterogeneity and ovarian cancer: a complicated tale from past to present

Ovarian cancer is composed of a complex system of cells best described by features such as clonal evolution, spatial and temporal genetic heterogeneity, and development of drug resistance, thus making it the most lethal gynecologic cancer. Seminal work on cancer as an evolutionary process has a long...

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Autores principales: Achimas-Cadariu, Patriciu, Kubelac, Paul, Irimie, Alexandru, Berindan-Neagoe, Ioana, Rühli, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9164402/
https://www.ncbi.nlm.nih.gov/pubmed/35659345
http://dx.doi.org/10.1186/s13048-022-01004-1
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author Achimas-Cadariu, Patriciu
Kubelac, Paul
Irimie, Alexandru
Berindan-Neagoe, Ioana
Rühli, Frank
author_facet Achimas-Cadariu, Patriciu
Kubelac, Paul
Irimie, Alexandru
Berindan-Neagoe, Ioana
Rühli, Frank
author_sort Achimas-Cadariu, Patriciu
collection PubMed
description Ovarian cancer is composed of a complex system of cells best described by features such as clonal evolution, spatial and temporal genetic heterogeneity, and development of drug resistance, thus making it the most lethal gynecologic cancer. Seminal work on cancer as an evolutionary process has a long history; however, recent cost-effective large-scale molecular profiling has started to provide novel insights coupled with the development of mathematical algorithms. In the current review, we have systematically searched for articles that focused on the clonal evolution of ovarian cancer to offer the whole landscape of research that has been done and highlight future research avenues given its characteristic features and connections to evolutionary biology.
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spelling pubmed-91644022022-06-05 Evolutionary perspectives, heterogeneity and ovarian cancer: a complicated tale from past to present Achimas-Cadariu, Patriciu Kubelac, Paul Irimie, Alexandru Berindan-Neagoe, Ioana Rühli, Frank J Ovarian Res Review Ovarian cancer is composed of a complex system of cells best described by features such as clonal evolution, spatial and temporal genetic heterogeneity, and development of drug resistance, thus making it the most lethal gynecologic cancer. Seminal work on cancer as an evolutionary process has a long history; however, recent cost-effective large-scale molecular profiling has started to provide novel insights coupled with the development of mathematical algorithms. In the current review, we have systematically searched for articles that focused on the clonal evolution of ovarian cancer to offer the whole landscape of research that has been done and highlight future research avenues given its characteristic features and connections to evolutionary biology. BioMed Central 2022-06-03 /pmc/articles/PMC9164402/ /pubmed/35659345 http://dx.doi.org/10.1186/s13048-022-01004-1 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Achimas-Cadariu, Patriciu
Kubelac, Paul
Irimie, Alexandru
Berindan-Neagoe, Ioana
Rühli, Frank
Evolutionary perspectives, heterogeneity and ovarian cancer: a complicated tale from past to present
title Evolutionary perspectives, heterogeneity and ovarian cancer: a complicated tale from past to present
title_full Evolutionary perspectives, heterogeneity and ovarian cancer: a complicated tale from past to present
title_fullStr Evolutionary perspectives, heterogeneity and ovarian cancer: a complicated tale from past to present
title_full_unstemmed Evolutionary perspectives, heterogeneity and ovarian cancer: a complicated tale from past to present
title_short Evolutionary perspectives, heterogeneity and ovarian cancer: a complicated tale from past to present
title_sort evolutionary perspectives, heterogeneity and ovarian cancer: a complicated tale from past to present
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9164402/
https://www.ncbi.nlm.nih.gov/pubmed/35659345
http://dx.doi.org/10.1186/s13048-022-01004-1
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