Histone deacetylase 3 facilitates TNFα-mediated NF-κB activation through suppressing CTSB induced RIP1 degradation and is required for host defense against bacterial infection

BACKGROUND: As important enzymes regulating acetylation, histone deacetylases (HDACs) participate in a series of cell physiological process. However, the mechanisms responsible for individual HDAC family members in regulating innate immunity remained to be elucidated. Here we sought to reveal the me...

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Detalles Bibliográficos
Autores principales: Yang, Liping, Chen, Shengchuan, Xia, Jingyan, Zhou, Ying, Peng, Linan, Fan, Huimin, Han, Yu, Duan, Lihua, Cheng, Genhong, Yang, Heng, Xu, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9164478/
https://www.ncbi.nlm.nih.gov/pubmed/35658939
http://dx.doi.org/10.1186/s13578-022-00814-6

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