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Nicotinamide drives T cell activation in the mammary tumor microenvironment
Nicotinamide (NAM, a variant of vitamin B(3)) has recently been shown to accelerate the activation of human CD4(+) and CD8(+) T cells exposed to repeated CD3/CD28 agonism in vitro. Here, we demonstrate that T cells infiltrating mouse mammary carcinomas that are therapeutically controlled by NAM also...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9164530/ https://www.ncbi.nlm.nih.gov/pubmed/35659314 http://dx.doi.org/10.1186/s12967-022-03454-z |