ATRT-26. The PI3k inhibitor Paxalisib combines with the novel HDAC1/3 inhibitor RG2833 to improve survival in mice bearing orthotopic xenografts of atypical teratoid/rhabdoid tumors

We previously identified high activation of mTORC1 and mTORC2 in AT/RT by immunohistochemistry of 18 primary tumors expanding over each molecular subgroup of AT/RT. Paxalisib is a highly brain-penetrant PI3k inhibitor acting upstream of mTORC1/2 to fully inhibit the activation of both complexes. Ong...

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Detalles Bibliográficos
Autores principales: Findlay, Tyler, Malebranche, Kristen, Raabe, Eric, Eberhart, Charles, Rubens, Jeffrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Atypical Teratoid Rhabdoid Tumor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9164640/
http://dx.doi.org/10.1093/neuonc/noac079.025

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9164640/
http://dx.doi.org/10.1093/neuonc/noac079.025

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