IMMU-14. SynNotch chimeric antigen receptor (CAR) T-cells as a potential treatment for diffuse intrinsic pontine glioma (DIPG)/diffuse midline glioma (DMG)

BACKGROUND: The development of effective chimeric antigen receptor (CAR) T-cell therapies for malignant pediatric brain tumors remains a challenge due to multiple barriers, including antigenic heterogeneity, on-target off-tumor toxicities, and T cell exhaustion. We have adopted a novel synthetic Not...

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Detalles Bibliográficos
Autores principales: Ferrerosa, Lauren, Simic, Milos, Watchmaker, Payal, Diebold, David, Pineo-Cavanaugh, Psalm, Deucker, Jason, Lim, Wendall, Okada, Hideho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Immunotherapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9164689/
http://dx.doi.org/10.1093/neuonc/noac079.307

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9164689/
http://dx.doi.org/10.1093/neuonc/noac079.307

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