MEDB-73. Lipid metabolism as a therapeutic vulnerability in BET inhibitor-resistant medulloblastoma

MYC-driven medulloblastomas are a particularly devastating group of pediatric brain tumors that exhibit resistance and continued progression despite standard of care treatments. Our preclinical work identified BET-bromodomain inhibitors as a potentially promising new class of drugs for children with...

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Detalles Bibliográficos
Autores principales: Lupien, Leslie, Boynton, Adam, Chacon, Madison, Kumbhani, Rushil, Gionet, Gabrielle, Goodale, Amy, Root, David, Keshishian, Hasmik, Robinson, Margaret, Carr, Steven, Bandopadhayay, Pratiti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Medulloblastoma
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9164697/
http://dx.doi.org/10.1093/neuonc/noac079.447

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9164697/
http://dx.doi.org/10.1093/neuonc/noac079.447

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