NFB-08. TRAM-01: A Phase 2 study of trametinib for pediatric patients with neurofibromatosis type 1 and plexiform neurofibromas

BACKGROUND: Plexiform neurofibromas (PN) are found in up to 50% of patients with neurofibromatosis type 1 (NF1). Trametinib has been used widely to treat PN but limited data has been reported on its efficacy within a clinical trial. METHODS: This ongoing multicenter phase II trial includes patients...

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Detalles Bibliográficos
Autores principales: Kiaei, Dorsa Sadat, Larouche, Valérie, Décarie, Jean-Claude, Tabori, Uri, Hawkin, Cynthia, Lippé, Sarah, Ellezam, Benjamin, Ospina, Luis H, Théoret, Yves, Desjardins, Léandra, Métras, Marie-Élaine, Sultan, Serge, Cantin, Édith, Routhier, Marie-Ève, Mailloux, Chantal, Bertrand, Marie-Claude, Caru, Maxime, Vairy, Stéphanie, Legault, Geneviève, Bouffet, Éric, Ramaswamy, Vijay, Coltin, Hallie, Lafay-Cousin, Lucie, Hukin, Juliette, Erker, Craig, Jabado, Nada, Dehaes, Mathieu, Perreault, Sébastien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Neurofibromatosis and other Predisposition Syndromes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9164745/
http://dx.doi.org/10.1093/neuonc/noac079.472

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9164745/
http://dx.doi.org/10.1093/neuonc/noac079.472

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