MEDB-62. Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation

Genomic studies in medulloblastoma have identified distinct disease subgroups: wnt/wingless (WNT), sonic hedgehog (SHH), and non-WNT/non-SHH, comprising group 3 and group 4. Alterations in WNT and SHH signalling form the pathogenetic basis for their subgroups, whereas those for non-WNT/non-SHH tumou...

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Detalles Bibliográficos
Autores principales: Chen, Zhuoyao, Ioris, Rafael, Richardson, Stacey, Van Ess, Ava, Vendrell, Iolanda, Kessler, Benedikt, Buffa, Francesca, Busino, Luca, Clifford, Steven, Bullock, Alex, D'Angiolella, Vincenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Medulloblastoma
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9164748/
http://dx.doi.org/10.1093/neuonc/noac079.436

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9164748/
http://dx.doi.org/10.1093/neuonc/noac079.436

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