DIPG-52. Activators of the integrated stress response synergize to kill DIPG

DIPG has elevated baseline activation of the integrated stress response (ISR), an evolutionarily conserved system that allows cells to tolerate various forms of stress. Increased expression of activating transcription factor 4 (ATF4) indicates activation of the ISR. Intermediate levels of ATF4 prote...

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Detalles Bibliográficos
Autores principales: Novak, Orlandi, Arnold, Antje, Eberhart, Charles, Raabe, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Diffuse Midline Glioma/DIPG
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9164858/
http://dx.doi.org/10.1093/neuonc/noac079.109

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9164858/
http://dx.doi.org/10.1093/neuonc/noac079.109

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