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DYRK1A reinforces epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma via cooperatively activating STAT3 and SMAD

BACKGROUND: Hepatocellular carcinoma (HCC) accounts for the majority of liver cancer cases, while metastasis is considered the leading cause of HCC-related death. However, the currently available treatment strategies for efficient suppression of metastasis are limited. Therefore, novel therapeutic t...

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Detalles Bibliográficos
Autores principales: Li, Yang-ling, Zhang, Man-man, Wu, Lin-wen, Liu, Ye-han, Zhang, Zuo-yan, Zeng, Ling-hui, Lin, Neng-ming, Zhang, Chong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9164892/
https://www.ncbi.nlm.nih.gov/pubmed/35655269
http://dx.doi.org/10.1186/s12929-022-00817-y