Cargando…

DYRK1A reinforces epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma via cooperatively activating STAT3 and SMAD

BACKGROUND: Hepatocellular carcinoma (HCC) accounts for the majority of liver cancer cases, while metastasis is considered the leading cause of HCC-related death. However, the currently available treatment strategies for efficient suppression of metastasis are limited. Therefore, novel therapeutic t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Yang-ling, Zhang, Man-man, Wu, Lin-wen, Liu, Ye-han, Zhang, Zuo-yan, Zeng, Ling-hui, Lin, Neng-ming, Zhang, Chong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9164892/ https://www.ncbi.nlm.nih.gov/pubmed/35655269 http://dx.doi.org/10.1186/s12929-022-00817-y

Ejemplares similares

DYRK1A inhibition suppresses STAT3/EGFR/Met signalling and sensitizes EGFR wild‐type NSCLC cells to AZD9291
por: Li, Yang‐ling, et al.
Publicado: (2019)

Brusatol suppresses STAT3-driven metastasis by downregulating epithelial-mesenchymal transition in hepatocellular carcinoma
por: Lee, Jong Hyun, et al.
Publicado: (2020)

DYRK1A suppression attenuates HIF-1α accumulation and enhances the anti-liver cancer effects of regorafenib and sorafenib under hypoxic conditions
por: Zhang, Chong, et al.
Publicado: (2022)

KIAA1217 Promotes Epithelial-Mesenchymal Transition and Hepatocellular Carcinoma Metastasis by Interacting with and Activating STAT3
por: Wang, Yanhong, et al.
Publicado: (2021)

Goosecoid Promotes the Metastasis of Hepatocellular Carcinoma by Modulating the Epithelial-Mesenchymal Transition
por: Xue, Tong-Chun, et al.
Publicado: (2014)

JPHYD Inhibits miR-21-5p/Smad7-Mediated Epithelial-Mesenchymal Transition of Hepatocellular Carcinoma Cells
por: Liu, Li-Hua, et al.
Publicado: (2022)

DYRK2 downregulation in colorectal cancer leads to epithelial–mesenchymal transition induction and chemoresistance
por: Wu, Chunrong, et al.
Publicado: (2022)

The Chinese Medicine, Jiedu Recipe, Inhibits the Epithelial Mesenchymal Transition of Hepatocellular Carcinoma via the Regulation of Smad2/3 Dependent and Independent Pathways
por: Liang, Shufang, et al.
Publicado: (2018)

Corrigendum to “The Chinese Medicine, Jiedu Recipe, Inhibits the Epithelial Mesenchymal Transition of Hepatocellular Carcinoma via the Regulation of Smad2/3 Dependent and Independent Pathways”
por: Liang, Shufang, et al.
Publicado: (2022)

circSMAD2 inhibits the epithelial–mesenchymal transition by targeting miR-629 in hepatocellular carcinoma
por: Zhang, Xianwei, et al.
Publicado: (2018)

RNA Binding Motif Protein 3 Promotes Cell Metastasis and Epithelial–Mesenchymal Transition Through STAT3 Signaling Pathway in Hepatocellular Carcinoma
por: Zhang, Lu, et al.
Publicado: (2022)

Overexpression of SIRT1 promotes metastasis through epithelial-mesenchymal transition in hepatocellular carcinoma
por: Hao, Chong, et al.
Publicado: (2014)

NEDD9 may regulate hepatocellular carcinoma cell metastasis by promoting epithelial-mesenchymal-transition and stemness via repressing Smad7
por: Wang, Zhipeng, et al.
Publicado: (2016)

IGF-1 induces the epithelial-mesenchymal transition via Stat5 in hepatocellular carcinoma
por: Zhao, Chuanzong, et al.
Publicado: (2017)

Gankyrin promotes epithelial-mesenchymal transition and metastasis in NSCLC through forming a closed circle with IL-6/ STAT3 and TGF-β/SMAD3 signaling pathway
por: Wang, Wu-ping, et al.
Publicado: (2016)

CDCA7 promotes TGF‐β‐induced epithelial–mesenchymal transition via transcriptionally regulating Smad4/Smad7 in ESCC
por: Li, Hongyi, et al.
Publicado: (2022)

Silencing Smad4 attenuates sensitivity of colorectal cancer cells to cetuximab by promoting epithelial-mesenchymal transition
por: Lin, Zhenlv, et al.
Publicado: (2019)

Silencing of Long Non-coding RNA SMAD5-AS1 Reverses Epithelial Mesenchymal Transition in Nasopharyngeal Carcinoma via microRNA-195-Dependent Inhibition of SMAD5
por: Li, Siwei, et al.
Publicado: (2019)

Protopanaxadiol inhibits epithelial–mesenchymal transition of hepatocellular carcinoma by targeting STAT3 pathway
por: Yang, Lan, et al.
Publicado: (2019)

Calcitriol inhibits migration and invasion of renal cell carcinoma cells by suppressing Smad2/3‐, STAT3‐ and β‐catenin‐mediated epithelial‐mesenchymal transition
por: Xu, Shen, et al.
Publicado: (2020)

SMYD3 induces sorafenib resistance by activating SMAD2/3-mediated epithelial-mesenchymal transition in hepatocellular carcinoma
por: Wang, Shanshan, et al.
Publicado: (2023)

FYN promotes gastric cancer metastasis by activating STAT3-mediated epithelial-mesenchymal transition
por: Yu, Jie, et al.
Publicado: (2020)

Collagen XV mediated the epithelial-mesenchymal transition to inhibit hepatocellular carcinoma metastasis
por: Yao, Ting, et al.
Publicado: (2022)

CircFGGY Inhibits Cell Growth, Invasion and Epithelial-Mesenchymal Transition of Hepatocellular Carcinoma via Regulating the miR-545-3p/Smad7 Axis
por: Feng, Kun-Liang, et al.
Publicado: (2022)

MicroRNA-32-5p inhibits epithelial-mesenchymal transition and metastasis in lung adenocarcinoma by targeting SMAD family 3
por: Zhang, Jin-Xing, et al.
Publicado: (2021)

Hypoxia Promotes Epithelial - Mesenchymal Transition of Hepatocellular Carcinoma Cells via Inducing GLIPR-2 Expression
por: Huang, Shao-guang, et al.
Publicado: (2013)

Treatment with the herbal formula Songyou Yin inhibits epithelial-mesenchymal transition in hepatocellular carcinoma through downregulation of TGF-β1 expression and inhibition of the SMAD2/3 signaling pathway
por: Zheng, Susu, et al.
Publicado: (2017)

MicroRNA-182 targets SMAD7 to potentiate TGFβ-induced epithelial-mesenchymal transition and metastasis of cancer cells
por: Yu, Jingyi, et al.
Publicado: (2016)

Mesenchymal Stem Cells in Inflammation Microenvironment Accelerates Hepatocellular Carcinoma Metastasis by Inducing Epithelial-Mesenchymal Transition
por: Jing, Yingying, et al.
Publicado: (2012)

TIM-3 Participates in the Invasion and Metastasis of Nasopharyngeal Carcinoma via SMAD7/SMAD2/SNAIL1 Axis-Mediated Epithelial-Mesenchymal Transition
por: Xiao, Yangyang, et al.
Publicado: (2020)

MicroRNA-10b regulates epithelial–mesenchymal transition by modulating KLF4/KLF11/Smads in hepatocellular carcinoma
por: Hujie, Gulibaha, et al.
Publicado: (2018)

TROAP switches DYRK1 activity to drive hepatocellular carcinoma progression
por: Li, Lei, et al.
Publicado: (2021)

High-dose vitamin C suppresses the invasion and metastasis of breast cancer cells via inhibiting epithelial-mesenchymal transition
por: Zeng, Ling-Hui, et al.
Publicado: (2019)

miR-4775 promotes colorectal cancer invasion and metastasis via the Smad7/TGFβ-mediated epithelial to mesenchymal transition
por: Zhao, Senlin, et al.
Publicado: (2017)

Metabolic switch and epithelial–mesenchymal transition cooperate to regulate pluripotency
por: Sun, Hao, et al.
Publicado: (2020)

RHOJ Induces Epithelial-to-Mesenchymal Transition by IL-6/STAT3 to Promote Invasion and Metastasis in Gastric Cancer
por: Ma, Zhijie, et al.
Publicado: (2023)

TGF-β/SMAD4-Regulated LncRNA-LINP1 Inhibits Epithelial-Mesenchymal Transition in Lung Cancer
por: Zhang, Chong, et al.
Publicado: (2018)

Oncostatin M promotes cancer cell plasticity through cooperative STAT3-SMAD3 signaling
por: Junk, D J, et al.
Publicado: (2017)

Smurf2 suppresses the metastasis of hepatocellular carcinoma via ubiquitin degradation of Smad2
por: Song, Dongqiang, et al.
Publicado: (2022)

Cooperation of Cancer Stem Cell Properties and Epithelial-Mesenchymal Transition in the Establishment of Breast Cancer Metastasis
por: Hayashida, Tetsu, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_mllj0pllqrt11g5vi16ajsrum6