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HGG-25. Targeting KLF5 reduces tumorigenic phenotype in a murine glioblastoma (GBM) model

Sex differences are evident in the incidence, therapeutic response and survival of patients with various cancers including the most common, aggressive and incurable GBM. We generated a murine GBM model of male and female astrocytes with dual loss of NF1 and P53 that yielded a sex-biased transformati...

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Detalles Bibliográficos
Autores principales: Abou-Antoun, Tamara, Kfoury, Najla, Yang, Lihua, Warrington, Nicole, Chen, Xuhua, Reiss, India, Wilkinson, Michael, Mitra, Robi, Rubin, Josh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9164955/
http://dx.doi.org/10.1093/neuonc/noac079.240