IMMU-23. Novel gene-edited CAR-T cell therapy against Diffuse Intrinsic Pontine Glioma

BACKGROUND: We identified high expression of CD99 in DIPG tumors and developed a CAR using our newly identified single chain variable fragment (scFv) targeting CD99 incorporating a 4-1BB co-stimulatory domain. This CD99 CAR demonstrated the ability to dramatically shrink the established orthotopic D...

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Detalles Bibliográficos
Autores principales: Balakrishnan, Ilango, Leach, Lillie, Lakshmanachetty, Senthilnath, Pierce, Angela, Madhavan, Krishna, Chatwin, Hannah, Fosmire, Susan, Meadows, Christina, Green, Adam, Fry, Terry, Vibhakar, Rajeev, Kohler, Eric M, Venkataraman, Sujatha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Immunotherapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9165007/
http://dx.doi.org/10.1093/neuonc/noac079.316

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9165007/
http://dx.doi.org/10.1093/neuonc/noac079.316

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