LGG-27. Molecular implications of mitogen-activated protein kinase pathway inhibition by the MEK inhibitor trametinib in BRAF-fusion-driven pediatric pilocytic astrocytoma

Pilocytic astrocytomas (PA) are the most common pediatric brain tumors. They are characterized by driving alterations in the mitogen-activated protein kinase (MAPK) pathway, leading to its constitutive activation and modulating the balance between cell proliferation and oncogene-induced senescence (...

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Detalles Bibliográficos
Autores principales: Sigaud, Romain, Stefanski, Anja, Selt, Florian, Hielscher, Thomas, Usta, Diren, Kocher, Daniela, Picard, Daniel, Büdenbender, Isabel, Remke, Marc, Pfister, Stefan M, Jones, David T W, Brummer, Tilman, Witt, Olaf, Milde, Till
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Low Grade Glioma
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9165015/
http://dx.doi.org/10.1093/neuonc/noac079.341

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9165015/
http://dx.doi.org/10.1093/neuonc/noac079.341

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