MEDB-81. Combined inhibition of CDK11 and EZH2 results in regression of MYC-amplified medulloblastoma

We explored an shRNA library screen on 20 cyclin-dependent kinases to establish cyclin-dependent kinase 11 (CDK11) as a critical mediator in MYC-driven medulloblastoma. The effect and molecular mechanism of CDK11 in the proliferation and growth of medulloblastoma were investigated in vitro. Pharmace...

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Detalles Bibliográficos
Autores principales: Wang, Dong, Veo, Bethany, Pierce, Angela, Venkataraman, Sujatha, Vibhakar, Rajeev
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Medulloblastoma
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9165029/
http://dx.doi.org/10.1093/neuonc/noac079.455

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9165029/
http://dx.doi.org/10.1093/neuonc/noac079.455

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