MEDB-11. MYC overexpression and SMARCA4 loss in cerebellar granule cell precursors cooperate to drive medulloblastoma formation in mice

Group 3 medulloblastoma is one of the most aggressive types of childhood brain tumors. Roughly 30 % of cases carry genetic alterations in MYC, SMARCA4 or both genes combined. While overexpression of MYC has previously been shown to drive medulloblastoma formation in mice, the functional significance...

Descripción completa

Detalles Bibliográficos
Autores principales: Göbel, Carolin, Holdhof, Dörthe, Schoof, Melanie, Kresbach, Catena, Schüller, Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Medulloblastoma
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9165048/
http://dx.doi.org/10.1093/neuonc/noac079.386

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9165048/
http://dx.doi.org/10.1093/neuonc/noac079.386

Ejemplares similares