DIPG-20. Copper chelation therapy targets S-adenosylmethionine (SAM) metabolism and epigenetic regulators in diffuse intrinsic pontine glioma (DIPG)

DIPG is an incurable pediatric brain cancer of the ventral pons characterized by its complex epigenetic profile. Up to 81% of patients present with mutation H3K27M, resulting in the global reduction of H3K27 trimethylation and increased H3K27 acetylation, deregulating gene expression through an aber...

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Detalles Bibliográficos
Autores principales: Michniewicz, Filip, Bell, Jessica, Saletta, Federica, Watkinson, Tayla, Mercatelli, Daniele, Giorgi, Federico M, Barlow, Christopher K, Faridi, Pouya, Tsoli, Maria, Ziegler, David, Vittorio, Orazio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Diffuse Midline Glioma/DIPG
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9165078/
http://dx.doi.org/10.1093/neuonc/noac079.077

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9165078/
http://dx.doi.org/10.1093/neuonc/noac079.077

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