DIPG-26. Targeted Protein Degradation of LSD1 synergizes with HDAC inhibitors in Diffuse Intrinsic Pontine Glioma

Diffuse intrinsic pontine glioma (DIPG) remains one of the most lethal brain tumors in all of childhood with no effective treatments besides radiation, which only extends survival a few months. Against this backdrop, our lab recently executed a focused CRISPR negative selection screen in DIPG cell l...

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Detalles Bibliográficos
Autores principales: Groves, Andrew, Poetschke, Rebecca, Mire, Hafsa, Panditharatna, Eshini, Guzman, Maria Tarazona, Qi, Jun, Filbin, Mariella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Diffuse Midline Glioma/DIPG
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9165079/
http://dx.doi.org/10.1093/neuonc/noac079.083

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9165079/
http://dx.doi.org/10.1093/neuonc/noac079.083

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