IMMU-01. Combining CD28 and 4-1BB costimulationin trans enhances the anti-glioma efficacy and persistence of B7-H3 CAR T cells in immune-competent brain tumor models

We and others have demonstrated that B7-H3 CAR T-cells have potent antitumor responses in xenograft models for brain tumors; however, these models do not recapitulate the immunosuppressive tumor microenvironment (TME) in patients with high-grade glioma. To evaluate the safety and efficacy of antigen...

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Detalles Bibliográficos
Autores principales: Haydar, Dalia, Elayan, Abdul, Yi, Zhongzhen, Gottschalk, Stephen, DeRenzo, Chris, Krenciute, Giedre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Immunotherapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9165103/
http://dx.doi.org/10.1093/neuonc/noac079.294

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9165103/
http://dx.doi.org/10.1093/neuonc/noac079.294

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