EPEN-26. Chemokine receptor blockade reverses CCL2 mediated immunosuppression and restores CAR-T cell function in posterior fossa ependymoma

Trastuzumab-based HER2 CAR-T constructs have demonstrated preclinical efficacy in medulloblastoma and are being evaluated for use in children and young adults with recurrent or refractory CNS tumors. Preliminary results demonstrate immune activation but no objective tumor response in three patients,...

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Detalles Bibliográficos
Autores principales: Cole, Allison P, Donson, Andrew M, Pierce, Angela M, Grimaldo, Enrique, Calhoun, Jacob D, Griesinger, Andrea M, Sublett, Caroline, Kaplan, Rosandra N, Fry, Terry J, Foreman, Nicholas K, Nellan, Anandani
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Ependymoma
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9165124/
http://dx.doi.org/10.1093/neuonc/noac079.162

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9165124/
http://dx.doi.org/10.1093/neuonc/noac079.162

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