HGG-20. PRMT5 promotes the formation and growth of pediatric high-grade glioma by maintaining tumor stem cell populations

BACKGROUND: Pediatric high-grade gliomas (PHGG) are aggressive, undifferentiated CNS tumors comprising two broad subtypes: diffuse midline glioma with H3K27M mutations (DMG) and cortical high-grade glioma (H3K27-wild-type (wt) PHGG). During normal development, PRMT5 promotes stem cell self-renewal t...

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Detalles Bibliográficos
Autores principales: DeSisto, John, Knox, Aaron, Balakrishnan, Ilango, Chatwin, Hannah, Coleman, Philip, Venkataraman, Sujatha, Vibhakar, Rajeev, Green, Adam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
High Grade Glioma
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9165164/
http://dx.doi.org/10.1093/neuonc/noac079.235

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9165164/
http://dx.doi.org/10.1093/neuonc/noac079.235

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