LGG-55. Autophagy sensitizes CNS tumors to targeted therapy by lowering their apoptotic threshold

Autophagy inhibition improves the effectiveness and overcomes RAF pathway inhibition (RAFi) resistance across multiple CNS tumors and molecularly distinct resistance mechanisms. Mechanistic links between autophagy and apoptotic cell death may explain this ability to improve RAFi response and reverse...

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Detalles Bibliográficos
Autores principales: Crespo, Michele, Zahedi, Shadi, Morin, Andrew, Wodetzki, Darya, Caino, Cecilia, Levy, Jean Mulcahy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Low Grade Glioma
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9165170/
http://dx.doi.org/10.1093/neuonc/noac079.367

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9165170/
http://dx.doi.org/10.1093/neuonc/noac079.367

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