ATRT-01. Reconstitution of cGAS/ STING pathway via epigenetic reprogramming leads to anti-viral inflammatory signaling in Atypical teratoid rhabdoid tumors (ATRTs)

BACKGROUND: Atypical teratoid rhabdoid tumors (ATRTs) are highly aggressive brain tumors that affect young children characterized by biallelic inactivation of the SMARCB1 gene. Though patients benefit from multimodal therapy, there is no improvement in overall survival which necessitates the explora...

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Detalles Bibliográficos
Autores principales: Mangoli, Avani, Hariharan, Seetha, Ashley, David, Fuller, Rebecca, Bowie, Michelle, Briley, Aaron, Brown, Michael, Hostettler, Janell
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Atypical Teratoid Rhabdoid Tumor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9165189/
http://dx.doi.org/10.1093/neuonc/noac079.000

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9165189/
http://dx.doi.org/10.1093/neuonc/noac079.000

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