IMMU-16. Next-generation CAR T-cells targeting IL13RA2 and secreting IL-15 achieve durable tumour clearance in pre-clinical model of diffuse midline glioma

T-cells engineered with a chimeric antigen receptor (CAR) to acquire tumour specificity provide a possible new treatment approach for childhood brain tumours. Durable clinical remissions have been achieved with CD19-directed CAR T-cells in refractory B-cell malignancies including control of leptomen...

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Detalles Bibliográficos
Autores principales: Hotblack, Alastair, Wawrzyniecka, Patrycja, Cheng, Gordon Weng-Kit, Nannini, Francesco, Pule, Martin, Straathof, Karin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Immunotherapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9165357/
http://dx.doi.org/10.1093/neuonc/noac079.309

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9165357/
http://dx.doi.org/10.1093/neuonc/noac079.309

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