Targeting mitochondrial DNA polymerase gamma for selective inhibition of MLH1 deficient colon cancer growth

Synthetic lethality in DNA repair pathways is an important strategy for the selective treatment of cancer cells without harming healthy cells and developing cancer-specific drugs. The synthetic lethal interaction between the mismatch repair (MMR) protein, MutL homolog 1 (MLH1), and the mitochondrial...

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Detalles Bibliográficos
Autores principales: Somuncu, Berna, Ekmekcioglu, Aysegul, Antmen, Fatma Merve, Ertuzun, Tugce, Deniz, Emre, Keskin, Nazli, Park, Joon, Yazici, Ilgu Ece, Simsek, Busra, Erman, Batu, Yin, Whitney, Erman, Burak, Muftuoglu, Meltem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9165880/
https://www.ncbi.nlm.nih.gov/pubmed/35657956
http://dx.doi.org/10.1371/journal.pone.0268391

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9165880/
https://www.ncbi.nlm.nih.gov/pubmed/35657956
http://dx.doi.org/10.1371/journal.pone.0268391

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