Cargando…

CD4 T-cell depletion prevents Lassa fever associated hearing loss in the mouse model

Lassa virus (LASV) is the causative agent of Lassa fever (LF), which presents as a lethal hemorrhagic disease in severe cases. LASV-induced hearing loss in survivors is a huge socioeconomic burden, however, the mechanism(s) leading to hearing loss is unknown. In this study, we evaluate in a mouse LF...

Descripción completa

Detalles Bibliográficos
Autores principales:	Maruyama, Junki, Reyna, Rachel A., Kishimoto-Urata, Megumi, Urata, Shinji, Manning, John T., Harsell, Nantian, Cook, Rebecca, Huang, Cheng, Nikolich-Zugich, Janko, Makishima, Tomoko, Paessler, Slobodan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9166448/ https://www.ncbi.nlm.nih.gov/pubmed/35605008 http://dx.doi.org/10.1371/journal.ppat.1010557

Ejemplares similares

Recovery of anosmia in hamsters infected with SARS-CoV-2 is correlated with repair of the olfactory epithelium
por: Reyna, Rachel A., et al.
Publicado: (2022)

Depletion of CD4 and CD8 T Cells Reduces Acute Disease and Is Not Associated with Hearing Loss in ML29-Infected STAT1-/- Mice
por: Reyna, Rachel A., et al.
Publicado: (2022)

Prolonged and extended impacts of SARS-CoV-2 on the olfactory neurocircuit
por: Kishimoto-Urata, Megumi, et al.
Publicado: (2022)

Lethal Infection of Lassa Virus Isolated from a Human Clinical Sample in Outbred Guinea Pigs without Adaptation
por: Maruyama, Junki, et al.
Publicado: (2019)

Epidemiological review of confirmed Lassa fever cases during 2016–2018, in Plateau State, North Central Nigeria
por: Gomerep, Simji, et al.
Publicado: (2022)

Animal Models of Lassa Fever
por: Sattler, Rachel A., et al.
Publicado: (2020)

Lassa fever–induced sensorineural hearing loss: A neglected public health and social burden
por: Mateer, Elizabeth J., et al.
Publicado: (2018)

Lassa virus isolates from Mali and the Ivory Coast represent an emerging fifth lineage
por: Manning, John T., et al.
Publicado: (2015)

Sequelae of Lassa Fever: Postviral Cerebellar Ataxia
por: Ezeomah, Chiomah, et al.
Publicado: (2019)

Role of Oxidative Stress and Antioxidants in Acquired Inner Ear Disorders
por: Kishimoto-Urata, Megumi, et al.
Publicado: (2022)

Lassa virus diversity and feasibility for universal prophylactic vaccine
por: Lukashevich, Igor S., et al.
Publicado: (2019)

T cell aging: naive but not young
por: Nikolich-Žugich, Janko
Publicado: (2005)

Ageing and life-long maintenance of T-cell subsets in the face of latent persistent infections
por: Nikolich-Žugich, Janko
Publicado: (2008)

Lassa virus NP DEDDh 3’-5’ exoribonuclease activity is required for optimal viral RNA replication
por: Huang, Cheng, et al.
Publicado: (2023)

Age-associated T-cell Clonal Expansions (TCE) in vivo—Implications for Pathogen Resistance
por: Nikolich-Žugich, Janko, et al.
Publicado: (2008)

Vaccine Candidates against Arenavirus Infections
por: Saito, Takeshi, et al.
Publicado: (2023)

729. Lassa Fever Associated Hearing Loss
por: Ficenec, Samuel, et al.
Publicado: (2021)

Predicting synkinesis caused by Bell's palsy or Ramsay Hunt syndrome using machine learning‐based logistic regression
por: Kishimoto‐Urata, Megumi, et al.
Publicado: (2023)

Review of Mammarenavirus Biology and Replication
por: Hallam, Steven J., et al.
Publicado: (2018)

Lassa fever-induced hearing loss: The neglected disability of hemorrhagic fever
por: Ficenec, Samuel C., et al.
Publicado: (2020)

Sensorineural hearing loss in Lassa fever: two case reports
por: Okokhere, Peter O, et al.
Publicado: (2009)

The roles of XJ13 and XJ44-specific mutations within the Candid #1 GPC in Junin virus attenuation
por: Manning, John Tyler, et al.
Publicado: (2023)

Potent Antiviral Activities of Type I Interferons to SARS-CoV-2 Infection
por: Mantlo, Emily, et al.
Publicado: (2020)

Antiviral activities of type I interferons to SARS-CoV-2 infection
por: Mantlo, Emily, et al.
Publicado: (2020)

Analysis of sensorineural hearing loss in patients attending an otolaryngology clinic in North Central Nigeria
por: Ma’an, Nuhu D., et al.
Publicado: (2023)

Imported Case of Lassa Fever in Sweden With Encephalopathy and Sensorineural Hearing Deficit
por: Grahn, Anna, et al.
Publicado: (2016)

A Review of Hearing Loss Associated with Zika, Ebola, and Lassa Fever
por: Ficenec, Samuel C., et al.
Publicado: (2019)

Lassa Fever 2016 Outbreak in Plateau State, Nigeria—The Changing Epidemiology and Clinical Presentation
por: Shehu, Nathan Y., et al.
Publicado: (2018)

Age-associated alterations in CD8α+ dendritic cells impair CD8 T-cell expansion in response to an intracellular bacterium
por: Li, Gang, et al.
Publicado: (2012)

Immune response to COVID-19 in older adults
por: Jergović, Mladen, et al.
Publicado: (2021)

Autophagy is essential for hearing in mice
por: Fujimoto, Chisato, et al.
Publicado: (2017)

Functional and Homeostatic Impact of Age-Related Changes in Lymph Node Stroma
por: Thompson, Heather L., et al.
Publicado: (2017)

Pathogenesis of Lassa Fever
por: Yun, Nadezhda E., et al.
Publicado: (2012)

A single mutation (V64G) within the RING Domain of Z attenuates Junin virus
por: Hallam, Steven J., et al.
Publicado: (2020)

Imported Lassa Fever, Pennsylvania, USA, 2010
por: Amorosa, Valerianna, et al.
Publicado: (2010)

Unbiased approach to identify and assess efficacy of human SARS-CoV-2 neutralizing antibodies
por: Cao, Xia, et al.
Publicado: (2022)

Key role of T cell defects in age-related vulnerability to West Nile virus
por: Brien, James D., et al.
Publicado: (2009)

A disconnect between precursor frequency, expansion potential, and site-specific CD4(+) T cell responses in aged mice
por: Deshpande, Neha R., et al.
Publicado: (2018)

Corrigendum: Defective Transcriptional Programming of Effector CD8 T Cells in Aged Mice Is Cell-Extrinsic and Can Be Corrected by Administration of IL-12 and IL-18
por: Jergović, Mladen, et al.
Publicado: (2020)

Defective Transcriptional Programming of Effector CD8 T Cells in Aged Mice Is Cell-Extrinsic and Can Be Corrected by Administration of IL-12 and IL-18
por: Jergović, Mladen, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_q4oe6h4bk2ssg36v2c58q7g0u2