SAR Probing of KX2-391 Provided Analogues With Juxtaposed Activity Profile Against Major Oncogenic Kinases

Tirbanibulin (KX2-391, KX-01), a dual non-ATP (substrate site) Src kinase and tubulin-polymerization inhibitor, demonstrated a universal anti-cancer activity for variety of cancer types. The notion that KX2-391 is a highly selective Src kinase inhibitor have been challenged by recent reports on the...

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Detalles Bibliográficos
Autores principales: Omar, Abdelsattar M., Khayat, Maan T., Ahmed, Farid, Muhammad, Yosra A., Malebari, Azizah M., Ibrahim, Sara M., Khan, Mohammad I., Shah, Dhaval K., Childers, Wayne E., El-Araby, Moustafa E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9166630/
https://www.ncbi.nlm.nih.gov/pubmed/35669422
http://dx.doi.org/10.3389/fonc.2022.879457

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9166630/
https://www.ncbi.nlm.nih.gov/pubmed/35669422
http://dx.doi.org/10.3389/fonc.2022.879457

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