Cargando…

SAR Probing of KX2-391 Provided Analogues With Juxtaposed Activity Profile Against Major Oncogenic Kinases

Tirbanibulin (KX2-391, KX-01), a dual non-ATP (substrate site) Src kinase and tubulin-polymerization inhibitor, demonstrated a universal anti-cancer activity for variety of cancer types. The notion that KX2-391 is a highly selective Src kinase inhibitor have been challenged by recent reports on the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Omar, Abdelsattar M., Khayat, Maan T., Ahmed, Farid, Muhammad, Yosra A., Malebari, Azizah M., Ibrahim, Sara M., Khan, Mohammad I., Shah, Dhaval K., Childers, Wayne E., El-Araby, Moustafa E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9166630/ https://www.ncbi.nlm.nih.gov/pubmed/35669422 http://dx.doi.org/10.3389/fonc.2022.879457

Ejemplares similares

Insights on Cancer Cell Inhibition, Subcellular Activities, and Kinase Profile of Phenylacetamides Pending 1H-Imidazol-5-One Variants
por: Khayat, Maan T., et al.
Publicado: (2022)

Molecular Mimics of Classic P-Glycoprotein Inhibitors as Multidrug Resistance Suppressors and Their Synergistic Effect on Paclitaxel
por: El-Araby, Moustafa E., et al.
Publicado: (2017)

Synthetic bulky NS4A peptide variants bind to and inhibit HCV NS3 protease
por: El-Araby, Moustafa E., et al.
Publicado: (2020)

1H-Imidazole-2,5-Dicarboxamides as NS4A Peptidomimetics: Identification of a New Approach to Inhibit HCV-NS3 Protease
por: Omar, Abdelsattar M., et al.
Publicado: (2020)

CRAF R391W is a melanoma driver oncogene
por: Atefi, Mohammad, et al.
Publicado: (2016)

SONY trinitron KX-14CP1
Publicado: (2017)

Endodontic Management of Teeth Juxtaposed to Haemangioma
por: Mani, Rekha Chandra, et al.
Publicado: (2017)

Potent Quinoline-Containing Combretastatin A-4 Analogues: Design, Synthesis, Antiproliferative, and Anti-Tubulin Activity
por: Ibrahim, Tarek S., et al.
Publicado: (2020)

The two EROS 4Kx8K CCD mosaic cameras
por: Bauer, F, et al.
Publicado: (1997)

Discovery of novel quinoline-based analogues of combretastatin A-4 as tubulin polymerisation inhibitors with apoptosis inducing activity and potent anticancer effect
por: Ibrahim, Tarek S., et al.
Publicado: (2021)

An Investigation of Structure-Activity Relationships of Azolylacryloyl Derivatives Yielded Potent and Long-Acting Hemoglobin Modulators for Reversing Erythrocyte Sickling
por: Omar, Abdelsattar M., et al.
Publicado: (2020)

Rabies elimination research: juxtaposing optimism, pragmatism and realism
por: Cleaveland, Sarah, et al.
Publicado: (2017)

Bioassay Guided Isolation and Docking Studies of a Potential β-Lactamase Inhibitor from Clutia myricoides
por: Elfaky, Mahmoud A., et al.
Publicado: (2020)

Juxtaposed atrial appendages: A curiosity with some clinical relevance
por: Singhi, Anil Kumar, et al.
Publicado: (2016)

Fungi as Endophytes in Artemisia thuscula: Juxtaposed Elements of Diversity and Phylogeny
por: Cosoveanu, Andreea, et al.
Publicado: (2018)

Antitumor Effect of KX-01 through Inhibiting Src Family Kinases and Mitosis
por: Kim, Seongyeong, et al.
Publicado: (2017)

Juxtapose: a gene-embedding approach for comparing co-expression networks
por: Ovens, Katie, et al.
Publicado: (2021)

Juxtaposing Medical Centers Using Different Questionnaires Through Score Predictors
por: Puga, Clara, et al.
Publicado: (2022)

Juxtaposing Sub-Sahara Africa’s energy poverty and renewable energy potential
por: Mukhtar, Mustapha, et al.
Publicado: (2023)

Probing juxtaposed G-quadruplex and hairpin motifs using a responsive nucleoside probe: a unique scaffold for chemotherapy
por: Khatik, Saddam Y., et al.
Publicado: (2023)

Structure of the AlgKX modification and secretion complex required for alginate production and biofilm attachment in Pseudomonas aeruginosa
por: Gheorghita, Andreea A., et al.
Publicado: (2022)

S391 The domestic animal revolution and infiuenza
por: Olsen, B.
Publicado: (2007)

Pilomatrixoma Arising Juxtaposed to Congenital Melanocytic Nevi: Concern for Malignant Degeneration? A Previously Unreported Association
por: Soteropulos, Carol. E, et al.
Publicado: (2016)

Assessments of Alpha-Amylase Inhibitory Potential of Tagetes Flavonoids through In Vitro, Molecular Docking, and Molecular Dynamics Simulation Studies
por: Mohamed, Gamal A., et al.
Publicado: (2023)

Extraction and identification of bioactive compounds (eicosane and dibutyl phthalate) produced by Streptomyces strain KX852460 for the biological control of Rhizoctonia solani AG-3 strain KX852461 to control target spot disease in tobacco leaf
por: Ahsan, Taswar, et al.
Publicado: (2017)

Regulation of closely juxtaposed proto-oncogene c-fms and HMGXB3 gene expression by mRNA 3′ end polymorphism in breast cancer cells
por: Woo, Ho-Hyung, et al.
Publicado: (2021)

Comparison of haematological parameters determined by the Sysmex KX - 2IN automated haematology analyzer and the manual counts
por: Ike, Samuel O, et al.
Publicado: (2010)

DEC Digital PDP11 H214 8KX16 Planar Core Memory
Publicado: (1972)

Role of L. plantarum KX519413 as Probiotic and Acacia Gum as Prebiotic in Gastrointestinal Tract Strengthening
por: Chundakkattumalayil, Honey Chandran, et al.
Publicado: (2019)

Sister DNA Entrapment between Juxtaposed Smc Heads and Kleisin of the Cohesin Complex
por: Chapard, Christophe, et al.
Publicado: (2019)

SAT-391 Perioperative Glucocorticoid Therapy for Patients with Adrenal Insufficiency: Dosing Based on Hydrocortisone Pharmacokinetic Data
por: Rahhal, Marie-Noel, et al.
Publicado: (2019)

Characterization of In Vivo Keratin 19 Phosphorylation on Tyrosine-391
por: Zhou, Qin, et al.
Publicado: (2010)

Abstract: Congenital Syndactyly Reconstruction of 391 Webspaces
por: Colen, David, et al.
Publicado: (2016)

Bik reduces hyperplastic cells by increasing Bak and activating DAPk1 to juxtapose ER and mitochondria
por: Mebratu, Yohannes A., et al.
Publicado: (2017)

Ret Finger Protein: An E3 Ubiquitin Ligase Juxtaposed to the XY Body in Meiosis
por: Gillot, Isabelle, et al.
Publicado: (2009)

Conformational plasticity underlies membrane fusion induced by an HIV sequence juxtaposed to the lipid envelope
por: de la Arada, Igor, et al.
Publicado: (2021)

Hemicentin-mediated type IV collagen assembly strengthens juxtaposed basement membrane linkage
por: Gianakas, Claire A., et al.
Publicado: (2022)

Translocations at 8q24 juxtapose MYC with genes that harbor superenhancers resulting in overexpression and poor prognosis in myeloma patients
por: Walker, B A, et al.
Publicado: (2014)

Fungal Bergamotane Sesquiterpenoids—Potential Metabolites: Sources, Bioactivities, and Biosynthesis
por: Khayat, Maan T., et al.
Publicado: (2022)

Application of response surface methodology for optimization of medium components for the production of secondary metabolites by Streptomyces diastatochromogenes KX852460
por: Ahsan, Taswar, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_nqc5u8c1b3j2u7p4ooqkreg78e