Overexpression of V-ATPase B2 attenuates lung injury/fibrosis by stabilizing lysosomal membrane permeabilization and increasing collagen degradation

Excessive oxidative stress causes lysosomal membrane permeabilization (LMP), which leads to cell death. Vacuolar ATPase (V-ATPase) is the enzyme responsible for pumping H(+) into the cytosol and thus maintaining intracellular pH. Previously, we reported that V-ATPase B2 subunit expression is upregul...

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Detalles Bibliográficos
Autores principales: Lee, Jong-Uk, Hong, Jisu, Shin, Hyesun, Ryu, Chnag-Beom, Park, Sung-Woo, Jeong, Sung Hwan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9166714/
https://www.ncbi.nlm.nih.gov/pubmed/35624153
http://dx.doi.org/10.1038/s12276-022-00776-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9166714/
https://www.ncbi.nlm.nih.gov/pubmed/35624153
http://dx.doi.org/10.1038/s12276-022-00776-2

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