Detoxified pneumolysin derivative ΔA146Ply inhibits autophagy and induces apoptosis in acute myeloid leukemia cells by activating mTOR signaling

Leukemia is caused by the malignant clonal expansion of hematopoietic stem cells, and in adults, the most common type of leukemia is acute myeloid leukemia (AML). Autophagy inhibitors are often used in preclinical and clinical models in leukemia therapy. However, clinically available autophagy inhib...

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Detalles Bibliográficos
Autores principales: Zhu, Tao, Zhang, Hong, Li, Sijie, Wu, Kaifeng, Yin, Yibing, Zhang, Xuemei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9166762/
https://www.ncbi.nlm.nih.gov/pubmed/35538212
http://dx.doi.org/10.1038/s12276-022-00771-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9166762/
https://www.ncbi.nlm.nih.gov/pubmed/35538212
http://dx.doi.org/10.1038/s12276-022-00771-7

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