The optimized core peptide derived from CABIN1 efficiently inhibits calcineurin-mediated T-cell activation

The C-terminal fragment of CABIN1 interacts with calcineurin and represses the transcriptional activity of the nuclear factor of activated T cells (NFAT). However, the specific sequences and mechanisms through which it binds to calcineurin are unclear. This study determined that decameric peptide (C...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Sangho, Lee, Han-Teo, Kim, Young Ah, Lee, Il-Hwan, Kang, Seong-Jun, Sim, Kyeongpyo, Park, Chung-Gyu, Choi, Kyungho, Youn, Hong-Duk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9166766/
https://www.ncbi.nlm.nih.gov/pubmed/35550603
http://dx.doi.org/10.1038/s12276-022-00772-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9166766/
https://www.ncbi.nlm.nih.gov/pubmed/35550603
http://dx.doi.org/10.1038/s12276-022-00772-6

Ejemplares similares