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The optimized core peptide derived from CABIN1 efficiently inhibits calcineurin-mediated T-cell activation
The C-terminal fragment of CABIN1 interacts with calcineurin and represses the transcriptional activity of the nuclear factor of activated T cells (NFAT). However, the specific sequences and mechanisms through which it binds to calcineurin are unclear. This study determined that decameric peptide (C...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9166766/ https://www.ncbi.nlm.nih.gov/pubmed/35550603 http://dx.doi.org/10.1038/s12276-022-00772-6 |