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Structures of a mammalian TRPM8 in closed state

Transient receptor potential melastatin 8 (TRPM8) channel is a Ca(2+)-permeable non-selective cation channel that acts as the primary cold sensor in humans. TRPM8 is also activated by ligands such as menthol, icilin, and phosphatidylinositol 4,5-bisphosphate (PIP(2)), and desensitized by Ca(2+). Her...

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Detalles Bibliográficos
Autores principales: Zhao, Cheng, Xie, Yuan, Xu, Lizhen, Ye, Fan, Xu, Ximing, Yang, Wei, Yang, Fan, Guo, Jiangtao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9166780/
https://www.ncbi.nlm.nih.gov/pubmed/35662242
http://dx.doi.org/10.1038/s41467-022-30919-y