The role of autophagy in cadmium-induced acute toxicity in glomerular mesangial cells and tracking polyubiquitination of cytoplasmic p53 as a biomarker

Cadmium (Cd) is a highly toxic environmental pollutant that can severely damage the kidneys. Here, we show that Cd-induced apoptosis is promoted by the cytoplasmic polyubiquitination of p53 (polyUb-p53), which is regulated by the polyubiquitination of SQSTM1/p62 (polyUb-p62) and autophagy in mouse k...

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Detalles Bibliográficos
Autores principales: Jung, Ki-Tae, Oh, Seon-Hee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9166781/
https://www.ncbi.nlm.nih.gov/pubmed/35624155
http://dx.doi.org/10.1038/s12276-022-00782-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9166781/
https://www.ncbi.nlm.nih.gov/pubmed/35624155
http://dx.doi.org/10.1038/s12276-022-00782-4

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