TGF-β promotes pericyte-myofibroblast transition in subretinal fibrosis through the Smad2/3 and Akt/mTOR pathways

Subretinal fibrosis remains a major obstacle to the management of neovascular age-related macular degeneration. Choroidal pericytes were found to be a significant source of subretinal fibrosis, but the underlying mechanisms of pericyte-myofibroblast transition (PMT) remain largely unknown. The goal...

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Detalles Bibliográficos
Autores principales: Zhao, Zhenzhen, Zhang, Yumeng, Zhang, Chaoyang, Zhang, Jingting, Luo, Xueting, Qiu, Qinghua, Luo, Dawei, Zhang, Jingfa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9166792/
https://www.ncbi.nlm.nih.gov/pubmed/35624154
http://dx.doi.org/10.1038/s12276-022-00778-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9166792/
https://www.ncbi.nlm.nih.gov/pubmed/35624154
http://dx.doi.org/10.1038/s12276-022-00778-0

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