GDAP1 loss of function inhibits the mitochondrial pyruvate dehydrogenase complex by altering the actin cytoskeleton

Charcot-Marie-Tooth (CMT) disease 4A is an autosomal-recessive polyneuropathy caused by mutations of ganglioside-induced differentiation-associated protein 1 (GDAP1), a putative glutathione transferase, which affects mitochondrial shape and alters cellular Ca(2+) homeostasis. Here, we identify the u...

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Detalles Bibliográficos
Autores principales: Wolf, Christina, Pouya, Alireza, Bitar, Sara, Pfeiffer, Annika, Bueno, Diones, Rojas-Charry, Liliana, Arndt, Sabine, Gomez-Zepeda, David, Tenzer, Stefan, Bello, Federica Dal, Vianello, Caterina, Ritz, Sandra, Schwirz, Jonas, Dobrindt, Kristina, Peitz, Michael, Hanschmann, Eva-Maria, Mencke, Pauline, Boussaad, Ibrahim, Silies, Marion, Brüstle, Oliver, Giacomello, Marta, Krüger, Rejko, Methner, Axel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9166793/
https://www.ncbi.nlm.nih.gov/pubmed/35662277
http://dx.doi.org/10.1038/s42003-022-03487-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9166793/
https://www.ncbi.nlm.nih.gov/pubmed/35662277
http://dx.doi.org/10.1038/s42003-022-03487-6

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