Ex vivo-expanded human CD19(+)TIM-1(+) regulatory B cells suppress immune responses in vivo and are dependent upon the TIM-1/STAT3 axis

Regulatory B cells (Breg) are a heterogenous population with immune-modulating functions. The rarity of human IL-10(+) Breg makes translational studies difficult. Here we report ex vivo expansion of human B cells with in vivo regulatory function (expBreg). CD154-stimulation of human CD19(+) B cells...

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Detalles Bibliográficos
Autores principales: Shankar, S., Stolp, J., Juvet, S. C., Beckett, J., Macklin, P. S., Issa, F., Hester, J., Wood, K. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9166804/
https://www.ncbi.nlm.nih.gov/pubmed/35660734
http://dx.doi.org/10.1038/s41467-022-30613-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9166804/
https://www.ncbi.nlm.nih.gov/pubmed/35660734
http://dx.doi.org/10.1038/s41467-022-30613-z

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